I know taking all these medications is scary, but they are tools to help you have a better life. Yes, Celebrex does have some side effects that you need to be aware of, but as long as your family doctor keeps monitoring your blood pressure and you keep taking the blood pressure medication I assume you've been prescribed, you've done everything you can to mitigate those side effects.   There are risks to taking the medications, but there are also risk to not take it. Uncontrolled RA can destroy your joints, which can destroy your life. Your ability to continue working, being active in your church, singing in your car, etc., depends on you taking the meds. At the end of the day, we all have to take a very clear-eyed look at the cost and benefit and to my thinking, it all comes down to what is your life worth? When you have a big problem, you need big solution and they come with a bigger risk. Biologics do have some risks, one of them higher incidence of certain forms of cancer, like melanoma or lymphoma, but you can do your best manage that risk by making sure you get annual checkups and wear sunblock. On the other hand, the Biologics also have a significant impact on the mortality gap, i.e., the fact that people with RA on average have a shorter life expectancy than others. There are studies that show that the Biologics improve your heart health and reduce your risk of heart attack and stroke.   Sweetie, your RA is really aggressive. I think you are at that point where you have to sit down and take a very serious look at what you're most afraid of: taking the drugs or losing your life. You can drive yourself crazy thinking about what might happen, but you have to remember to also think about what might happen if you don't take the medication. I know that on an intellectual level, you're right with me and if you were giving advice to someone else on this site, I know what you would say. Treat yourself like your own best friend and give yourself the best advice you can. Then close your eyes and jump in. I'll be right there with you, holding your hand.