My husband started out over 9 months ago with 10mg followed be 15mg of Prednisone daily. They added 20mg of Methotrexate once a week and 3 Folic Acid daily 6 months ago. They added once a week Enbrel injections 3+ months ago. He finally started showing results after 4 to 6 weeks of the Enbrel. Now they are trying to reduce the Prednisone, but when he drops below 10mg he breaks out in a terrible rash, oozing, bleeding and extremely painful. He has gained 100 pounds in the last 8 months due to the Prednisone. He is tired all the time. It is nothing for him to sleep 14+ hours after taking the Enbrel on Friday night and the Methotrexate on Saturday night. To give him credit he has not missed a day of work, only a few hours here and there for appointments. It is hard to watch someone who used to be so athletic reduced to this state. We are wondering about going somewhere for a second opinion. I realize Rheumatoid Arthritis cures are not an exact science, but his doctor is not very forthcoming with answers to questions. I am tired of watching him suffer.