I am a 39 year old woman who has had RA for about 12 years. I have been on several different DMARDS and combinations of medicines. My Rheumatologist is suggesting Rituxan. I have seen all of the warnings and side effects of the medicine and they are scary. But I am sure there are Pro's to this medicine that I simply can't find or don't understand because of all of the medical terminology. Do the benefits out weigh the risks? I have been on Celebrex 400 mg daily, Methotrexate 10 mg weekly, Plaquenil 200 mg daily, and Enbrel 50 mg weekly for a little over two years. I haven't taken any other Biological medicines. Should I try another one first? Because of my young age and the fact that I am a single mother, that works full time, I want to remain as active as possible for as long as possible !!! Any suggestions?