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Now I know I'm being obnoxious but I also just found this in my book.  Plaquenil.  I don't use this one so I don't know all that much about it.  It also doesn't seem to be as commonly prescribed as mtx and I'm not sure why BUT this is what I found:   "Hydroxychloroquine (Plaquenil) may be the safest of the DMARDs.  Estimates are that only 5 percent of patients discontinue using the medication because of its side effects.  The most commonly reported side effeccts of (Plaquenil) are nausea, decreased appetite, diarrhea, and rash.  Most of these problems can be eliminated with dose changes and by taking the medication at mealtime."   It goes on to say that the biggest concern with this drug is the rist of eye problems (retinopathy). Apparently though, if you get your eyes examined as advised every 6 mos. and stop immediately if the ophthamalogist tells you to, the risk of permanent eye damge approaches 0 percent.   So yeah, maybe ask about this one, huh?