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There appears to be a bit of a difference between the US and Canada in terms of how to treat RA - I've read many stories on the site where people get methotrexate along with a biologic and I'd never heard about it before. In Canada, they seem to do just a biologic.   I've been on Humira for two years and find that it takes about 4-6 weeks to really kick in. Yours may start to work sooner because you're taking prednisone - for quite a while, I found that Humira worked better when it had a bit of a boost from a steroid, although now I don't need the steroid so much anymore to get the full effect. I have experienced skin sensitivity to the sun and given that one of the side effects of Humira is a slightly greater risk of developing cancer, I would recommend not tanning and using sunblock, not sunscreen when you're by the pool. To be honest, although I understand that being tan can make you feel as if you're healthier and look better - I know I do - the increased rate of skin cancer that comes from years of tanning has made me think twice and once I started on Humira, I got out the sunblock. I can still be in the sun and enjoy the outside in the summer, but without risking melanoma.   That said, Humira has been wonderful for me. I am able to do more than I have before and live my life to a much greater extent than I have for a while. Also, I haven't had normal blood work in 40 years and now I do. It's my miracle drug. I hope it works the same for you.