The best advice I can give you is to speak to your rheumatologist about another medication. There's a reason they say absolutely, positively no alcohol with methotrexate and if your lifestyle makes that impossible, switch medications to stay safe and healthy.   Please understand that I'm not making any judgments about your lifestyle and neither should your doctor. It's important to have a life when you have a chronic illness - it can't all be about RA, because that's a surefire recipe for depression. You have a well-established life that gives you pleasure, which will help you get through the rough spots with RA and that includes your wine club and the good news is that there are a bunch of treatment options for you that will allow you to drink in moderation. Also, one of the benefits of a glass of wine is that it's a wonderful painkiller/muscle relaxant, as well as having been proven to be good for your heart.   In terms of your decrease in levels, to be honest, your doctor is a better person to ask about implications of that test result.   Good luck! Please let us know how things go? Down the line, if you're up to it, would you consider writing a SharePost about this experience? There's so much focus in our lives on medication and treatments that we often forget that the rest of life have to be lived, as well and I think it would be interesting for our users to read about your choice.