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Wow. That's a really big question. I'll start with a straightforward part. RA doesn't necessarily affect your ability to get pregnant. However, certain medications may make it more difficult to conceive. Methotrexate is one of those medications and as it can cause birth defects, if you're trying to conceive, you should speak to your rheumatologist about other options - they are a number of medications that are safer to take while pregnant/breast-feeding. Pregnancy itself may actually help your RA - I once heard a rheumatologist jokingly recommend that his female patients be pregnant as often as they could, as it can bring about a remission. You also asked if your RA will affect your married life and that's where it gets a little less straightforward to answer. In addition to the pain, RA can affect your energy levels, your mood (when you're not feeling well, you can get depressed) and your ability to do practical things around the house, as well as participate in leisure activities. However, people in general have different interests and abilities and just because you're healthy person, doesn't mean you like playing golf with your husband. In a relationship where one of the partners is sick, the other partner needs to be a flexible kind of person who can roll with the uncertainty that comes with living with RA. Honesty and good communication from the very beginning are key factors in coping with the third silent partner in the marriage - unfortunately, RA (or any other chronic disease) has a way of having a distinct presence. However, don't feel discouraged - it is very definitely possible to have a good relationship. You just have to find the right man for you, but that's not a unique question when you have a chronic disease - sit down with any group of women, especially single ones, and the question of how to find a good guy tends to dominate the conversation. Lastly, when people ask if something will affect their "married life", that can be a very polite way of asking about physical intimacy. In case that's what you meant, RA can affect your intimate life, as both pain and fatigue can interfere with desire. Depending on how well your RA is controlled, you may not have the kind of intimacy that involves swinging from the chandelier. In general, however, a bit of creativity, some good painkillers and a bit of research on the Internet on e.g., alternate positions can help you maintain a very healthy sex life. You can read more in this article.