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I have been on Methotrexzte many times throughout my disease within the past 11 years and from experience, methotrexate is NOT a medication you want to be on while trying to get pregnant. You MUST tell your doctor before you even attempt to become pregnant and he/she will place you on something else. I had become pregnant without telling my doctor that I was off my medication (I couldn't afford it for about 3 months) and upon hearing that I was pregnant, and I must say how upset he was when I first told him because this medication acts like birth control and he feared that I would have to consider aborting (awful term for killing my baby) but I reassured him of the fact that I hadn't had the medicine for 3 months so he knew that it was completely out of my system. I thank God for that major time in my life when I couldn't afford my medicine...He knew I was going to become pregnant and helped me through it all. As far as marriage or any kind of relationship, this disease will affect it SOMETIMES but if u find the right mate, one who is understanding and patient, you will go a long way with that. May God bless you in all you life's trials and relationships. Take care of yourself!!!!