Sunday, March 22, 2009 Debra, Community Member, asks

Q: Rituxan Infusion

Has anyone done Rituxan infusions? Starting mine this week and was wondering what to expect.

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Answers (5)
HLinNY, Community Member
3/23/09 4:42pm

Well, since no one else has answered this, I'll take a stab at it.


Let me say from the get go that I've never taken Rituxan for RA. I was, however, treated with it for Lymphoma 5 yrs ago. There may be some differences, but hopefully this will give you some idea of what to expect.


The infusion is given through an IV. My doctor gave me a dose of benedryl when I started, to avoid an allergic reaction. You nurse should monitor you carefully, to watch for any type of reaction. When I took it, I had to have the infusion very slowly, so I took about 5 hours. (Hopefully that's changed)


Afterwards, I had an immune response that felt similar to coming down with the flu- I was tired, achy, had a low level fever, and basically spent the rest of the day in bed. Now that I've got RA, that sounds pretty familiar. By the next morning, I was on my feet, but only moving at half-speed, and the day after that, I'd be fine.


I hope this helps you a little bit and good luck with your treatment! 



Peggy, Community Member
4/ 6/09 12:44pm

Hi.  Yes, I've done rituxan, 1 series, which in looking at the date, you have already done as well.  I hope it works as well for you as it has for me.  Within 3 days of the first dose I was feeling a bit better.  Now I am 5 weeks out from the second dose and I am walking 2 miles/day, exercising and feeling great!  I'm off prednisone for the first time in 14 months, no pain meds either.  I have a follow up in 3 days and can't wait to show my rheumy how well i'm doing!  Good luck to you!

kesha, Community Member
2/23/10 1:26pm

i this is my first dose and from reading everyones experience its making me scared. most of the time i dont read side affects on meds but this one was very curious to me. i wish i hadnt read it but i did. so now i need to put my scarriness behind me and get my treatment so i can soon say that im off prednisonewhich ive been on for the past ten yrs and that's not good. so pray for me and wish me luck like you had.


Kristina Place, Community Member
3/ 4/11 5:47am

getting ready for my first infusion treatment of Rituxian. After contending with RA for over 12 years and growing immunity to every prescription given to me I like yourself have been on predisone for quite sometime (over 3 years). Your blog has left me hopeful for as frightened as I am. Hoping this will put this debilitating desease to rest.

yourmama, Community Member
11/11/09 12:07pm

I have been taking it for over 3 years to treat RA. It worked wonders and I went back to feeling as well as I did before diagnosis. However that being said, I have now developed cancer of the uterus. They warned me that this could happen. Also, my mom has been on it for over a year, and she has developed something called PML. her condition has something to do with brain function. Hers is life threatening, and there is no known treatment. The medicine has done wonders for both of us as far as the ability to go back to a "normal" life of movement, just PLEASE never miss any appointments, and keep current on ALL LABS. if ANYTHING starts to feel different, see someone right away. Good luck to u all! (by the way, even with the cancer, I wouldnt trade the medicine for anything). I can have a hysterectomy to remove the cancer, but you cant have all your joints removed to walk ;)

Ronnie in Mass., Community Member
4/23/11 9:22am

I start these infusions next month because Enbrel & Humira didnt help.   I'm a little scared, but chronic pain for a long period of time will make you try just about anything....   Thanks for the posts, its always good to know what you are getting into.   Maybe some day they will find a cure for this!

Jodi G., Community Member
1/29/13 1:30pm

I have been doing Rituxan Infusions for several years and have had no problen

ms. They take a long time 5-6 hours in Chemo lab and I am tired after but ready to go the next day and feel better as time goes by.   I will bwe receiving mine next week and have gone 11 months between infusions this time.   Jodi

domamaldo, Community Member
3/20/14 11:36am

Got a shot of 120 mg prednisone in my butt ouchyyy ! Chest x-ray showed bronchitis and that horrible swab thing showed  sore throat . So I am taking antibiotics,  Tylenol and alternate motrin and prednisone pills to fix the swollen joints and allergic reaction. I had to use a wheel chair. No more wheel chair ever again! Healed in Jesus name. Thanks for prayers.  

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By Debra, Community Member— Last Modified: 03/20/14, First Published: 03/22/09