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I'v noticed that my skin is really crepey looking . It's probabally one of my meds, just not sure with one, so I slather on skin lotion all of the time. When I first started on the prednisone, and methotrexate, I itched real bad and would scratch till I was bleeding and bruised. Now I have cataracts that my dr. says is from taking prednisone...just can't win...lol