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Hi there!   Like you, I also have sero-negative RA. I second guess my diagnosis constantly, but the pain I feel snaps me back to reality quickly. Although I feel that I need to defend myself sometimes, like "even though the RF is negative I AM EXPERIENCING MASSIVE PAIN!!!" I dont like the way that feels. I too have very few good days despite all the drugs I am taking. My doc has tried multiple combos and apparently we still havent hit upon the winner (right now its Methotrexate, Lodine, Orencia). My husband commented that I have 2 speeds....bad and worse. Its the truth. I am 34 years old with 4 kids and  I feel so unable to shake this disease and get on with being young. I have always been healthy and only ever went to the doctors for allergies. I feel so overwhelmed and unsure about every move I make, every new drug I swallow and every new creak or groan my body makes. I was also a nurse, (I guess I technically still am, I just cant work any longer). I loved my job as a NICU nurse and that has been one of the hardest things to let go of. When your fingers can no longer grasp syringes,  attach a vent, or diaper a 1lb baby you are pretty useless on the unit!!  It wasnt just a profession, but a way to contribute to our financial well-being. This god forsaken disease effects every last part of your life, like when I cant color with my 4 year old or when I have to make my 14 year old chop veggies for dinner. I feel sad and so DEPENDENT, and I think thats the worst of it. I just want my life back...i havent fully come to terms with the new direction I have taken. I guess thats why I find myself here on this website...looking for answers and support.    All I can say is that my doc says that there are just some people out there who dont have a positive RF, but by all signs and symptoms there is no denying that we have RA. I have to remind myself of that all the time. I keep getting tested every so often to see if I convert, but I dont suppose that will really matter in the scheme of things as I have the pain, stiffness and limitations regardless of that one lab result. This is my life and I will manage it. So will you, there is no other choice. I wish you the best and as a nurse you know to keep searching for more info, find the best doctor and advocate for yourself. I am sorry that we are in this mess called RA! Good luck to you, I am sure better days are ahead.
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