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Hi there, I am also sero negative, and have been this way for sixteen yrs, although it took six yrs for it to be diagnosed correctly, Ive done some research on the internet, and im lead to believe that there can be a huge difference in the way the disease pans out over the yrs,between the neg/pos diagnose's, Although i have limited damage to my joints,IE swellings constantly around my knuckles, and swollen knees,nodules on the wrists, i feel like im in constant pain, Im taking Leflunomide 10mg as methotrexate made me poorly, Im also taking a low dosage of steroids at the moment due to my knees swellings up *Not Fun* Most days im confused by my RA, I cannot truly say ive felt in remission,I feel like im always entering a flare up stage, Ive never felt like a fraud when it comes to being diagnosed with sero neg though, because the proof is in the pain i feel, how much more real can it be? Im lucky that ive been abe to have two children, and feel the time spent pregant with them has helped my RA,also having another focus, yes constant worry to, helps me deal with my own problems...And keeps me active to:) I dont believe my life is over with this ill'ness, Im 35, and have plenty to look forward to, I also believe the early yrs are worse,due to the fact you find it hard to deal with RA,Once you except this is you,it doesnt go down hill from there, it actually makes you stronger, My advise would to try gain as much support around you as you can,and pace yourself,know your limits,mentally emotionaly,absorb as much info on self help, IE pain management,exercise,dont isolate yourself, and above all, keep positive......   Rachel xxx