Just wondering how long it takes before side effects of mehtotrexate are normally felt? I took my first dose this evening and am patiently awaiting the effects! lol! On another note wondering the best way to take this drug, I know my rhuematoligist said in the evening on an empty stomach and make sure I eat within 30 mins of taking the meds, also taking Folic acid and wondering would I take these together or seperate or what is the best way to take these (was given lots of infoat doctors office but details escaped me). I am still on prednisone and I take this in the morning with food. Any advice would be great, I am newly diagnoised and a little nervous of what to expect with all these new changes and things ahead!