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I frequently mess with my medication days based on holidays, birthdays and other occasions where I don't want to be dealing with side effects. However, I only did that after consultation with my doctor about when and how much I can mess with them and I really think you need to do the same. It's quite possible that you'll be able to push the day you take your meds a bit, but this is really something you need to run by your doctor first.   Keep in mind that you are your doctor's patient and your doctor is there to help you. Although I'm sure s/he became a doctor to help people, they are not doing this solely out of the goodness of their heart - this is what they do and that is what you pay them for, just as you'd pay for any other service or specialist, such as a mechanic, plumber or an interior decorator. Whether you pay your doctor directly or your insurance or another funding source pays them, they get paid to provide your medical care. Part of your medical care includes answering occasional questions in between appointments. Having a chronic disease like RA means that you need to become a strong advocate for yourself. I'm not telling you to get obnoxious about it, but remember that although your doctor is a member of your medical team, you are the leader of that team and this means not only that you need to take action when you have questions, but you also have a right to ask those questions.   Good luck with it and I hope your Christmas is happy and side effect free!