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I have been taking humira injections for about 3 years now and it is the best thing I have ever done for myself.  I was really quite nervous at first, but it truly doesn not hurt and you get used to doing it in no time.  Humira is now available in the pen form which is even easier.  The only thing I would suggest with the pen is to freeze the injection site for about 30 seconds before doing the injection as this prevents bruising.  I have not tried the infusions as the humira works so well for me, but i would much rather do a quick injection at home every other week than to have to go to the dr.'s office for 4 hours every 6 weeks.  Good luck and I hope you get results as good as mine are with which ever treatment you choose.