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Everyone responds differently to RA drugs. If you don't feel your body responding to the humira within a month or two, then you should talk to your doctor about it. You may continue to have flares and you may respond really well, even go into remission for a while. No drug will permanently cure the RA though.  Since Humira is an immune system inhibitor, it's really important to eat healthy, keep active and to get your flu shot and pneumoccal vaccine when they become available later this fall and to take extra precautions in public places by keeping your hands washed, etc.    When I started Humira, I noticed a difference within the first few injections and I felt great for about a year.  After a year, I went through a phase where I was getting a cold every month or so, which I don't normally do.  Then after that I began flaring more in between injections, so I eventually switched to Enbrel which is a once a week drug.  It is really common for one's body to "get used" to the drug(s) that you are taking, resulting in a need to switch up dosages or medications.  That's why it's important to have good communication with your rheumatologist.    I hope this is helpful.