I have written before, I have had 2 infusions of Remicade, one at 400 and then from some side effects the second was lowered to 300. The first one helped m yjoints immedealty and lasted for about 9 days, but the side effect to my bladder was terrible, so next infsuions they lowered it to 300 and gave me some sol-medrol no bladder but terribe joint pain, more than whe I was on enbrel, in fact i didn't have too much on enbrel just feed pain and the mri showed active disease. Can the remicade make your joints hurt more? My feet feel lik ethey are on fire and my big toe is so sore, not gout, the ra. My wirst ache it is so discouraging, I feel wowrse now that I ahve been on enbrel fo over a month. I am still on mtx, but lowered it cause of the stomach upset, on injectable too. down from 17.5 to 12 I am a wreck and gettig very very discouagred i do not go back now for a month I can't imagine, just was wonderfin how others did on it and what are your doses of the remicade?