it sounds to me as if methotrexate is not suppressing your RA. I had the same sort of experience with methotrexate, not just in terms of the stomach upset, but also that it wasn't doing enough. I then started Enbrel and got my life back. The pain was reduced significantly and this allowed me to build my life again.   you mentioned that you are on both Enbrel and methotrexate - is Enbrel alone not enough? If that is so, switching to another biologic may help you. You may want to consider talking to your rheumatologist about your options in terms of self injection vs. infusion. I started on Enbrel induces side effects, had to switch to Humira, which is also self injection. It depends on what works best for you - some people prefer self rejection even though it means taking the drug more often, whereas others prefer going to an infusion center every six weeks and getting it over with in one fell swoop.   Good luck! Please keep us posted?