Wednesday, October 22, 2014

Monday, November 23, 2009 acm363, Community Member, asks

Q: Is it possible to have RA with a negative RF and ANA test?

I have joint pain in my fingers, wrists, knees, elbows,and ankles on both sides for 3 months. The pain is worse at rest and at night and I also have fatigue, shortness of breath, nausau and weakness in my arms and legs. Does anyone have any ideas?

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Answers (3)
Lene Andersen, Health Guide
12/ 1/09 8:36pm

Absolutely - approximately 20% of people living with RA are seronegative, which means their labs tests are negative for RA.  we have it terrific post about lab results and what they mean that may give you more information.  The fact that you have joint pain and that it is symmetrical on both sides of your body could indicate that you have RA, so I would recommend you ask your doctor for a referral for rheumatologist as soon as possible and if you've already seen a rheumatologist, ask for referral to someone else.

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RD5470, Community Member
11/23/09 2:53pm

I have the exact same thing.  My initial tests for Rheumatoid came back negative.  I do have a second set out now.  They did find that I have a severe vitamin d deficiency.  Two of my 3 doctors think this may be the cause of all my problems. I am on a prescription vitamin d supplement of 50,000 iu a week I have to take for 3 months.  My doctor said it might take several months before I feel better.  My rheumatologist put me on prednisone to decrease the inflammation and help me feel better until they can find something that will work.  The prednisone works great, but gives me insomnia.  You might want to get your vitamin d checked.  It can cause bone and joint pain, swelling muscle loss and weakness.  Good luck!

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MelleBelle, Community Member
11/24/09 8:57am

Absolutely! I had migrating joint pain for almost 2 years, my sed rate, ANA, Rheumatoid Factor and thyroid all came back normal.  I changed insurance plans in July and switched to a new PCP.  She ran a blood test called an anti-CCP.  I did some research and it is a new test that is used in diagnosing RA when everything else is negative.  While I'm not thrilled to have RA, I am thrilled to know that something is causing the joint pain.  I've been on Plaquenil since my diagnosis in July and started Sulfasalazine in August.  I do have a bad day every now and then, but most of the time I feel "normal."  You might want to ask your Dr. about the anti-CCP.  Best wishes!

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By acm363, Community Member— Last Modified: 12/24/10, First Published: 11/23/09