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Oh the fatigue.  I deal with it too on a weekly basis.  I take 25mg a week, as maintenance until I can get on a biologic.  Here is the tricky thing that I like to explain to people about methotrexate.  Methotrexate can cause severe fatigue which in return can cause sever depression which also cause fatigue.  Now if you have recognized that it is purely fatigue from the methotrexate have no fear.  Slowly but surely the methotrexate will build up in your body and your side effects will become less severe.  Now I cannot promise you that the fatigue will go away.  It does for some, but I have been on it for over three years and experience fatigue.  Now I completely understand the anxiety of not being able to get up and do what needs to be done.  Here is something that might help, even out your days.  Here is what I do.  I make a list of things that need to be done throughout the week.  And instead of overduing it before I take my methotrexate (which makes the fatigue even more severe), even the chores out throughout the week. Say there are 5 important chores that need to be done throughout the weekdays.  Instead of doing two or three of them the days before you take you methotrexate (as we tend to do because we know the fatigue will knock us out) do one chore a day, even on the day you take your methotrexate.  If you can't accomplish it, then put it on the list for either the weekend or the next week.  You will find that it you don't overdue it before and after you take the methotrexate the fatigue won't be near as bad.  I hope this helps.  Good luck and best wishes!