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Hello,  Methotrexate is an immune supressant drug and supresses the immune system.  Yeah it does make one tired.   We are already immune supressed just by the rheumatoid.  When y add Methot. or Arava they make system even more supressed. (depressed ?)   Methot. works well for some and not for others.  I am off it and feel much better.It was not working for me - does not work for everyone.  However some do really well on it.   After 6 months or so ask yourself if it is really working.   Ask your Rheumy if you can go off it to see if there is any difference.  Go back on if there is.   Take calcium (citrate), check your Vitamin D levels, iron levels, thyroid too as this can effect RA.