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Methotrexate sure does take it out of you. When I was first put on it I had headaches and an upset stomach which could last a day or two. The next time you go to the doctor as about taking Folic acid. I found this helps me rebound from the effects of the methotrexate. I have been on methotrexate for 12 or so years and I am currently taking 17.5 mg a week. I take Folic acid on a daily basis and it really helps to the point I rarely feel the effects of the methotrexate.
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