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Hi Jeaneane,   I have too very close friends who have tried Flex Protex.   One friend needs two knee replacements and has arthritis in his hands.  He got noticable results in one and a half to two weeks and the benefits keept increasing the longer he was on it.  He is still on it and has no plans on stopping.  He is about 60 years old.   My other friend is going on 30 and has RA and has been taking the same medications you are prescribed for about 5 years.  Unfortunately the Flex Protex had no effect on her.  I beleive the effects of these medications countered the benefits of Flex Protex.   If you haven't tried the medications yet, you may want to consider trying Flex Protex first and see if you get similar results that my first friend had gotten.  If I am right taking Flex Protex after starting these medications will not benefit you.   Please feel free to email me.  I am being very honest especially since I sell Flex Protex.