FROM OUR EXPERTS
On Thursday, April 12 an FDA advisory panel will discuss
whether or not to recommend that the FDA approve Merck & Co’s COX-2
inhibitor, Arcoxia (etoricoxib). The drug is manufactured by Merck, the
same company that made Vioxx, which was pulled from the market in the fall of
2004. Merck applied for approval to sell Arcoxia as a treatment for the
signs and symptoms of osteoarthritis .
Currently, the only COX-2 inhibitor remaining on the market
is Celebrex , made by Pfizer, Inc. These COX-2 inhibitors are all types of
NSAIDs. Over the counter types of NSAIDs include naproxen (sold as Aleve)
and ibuprofen. The difference between the prescription COX-2s and the OTC
NSAIDS (and the big selling point) is that the COX-2s have a lower risk of
bleeding ulcers and other GI complications than other NSAIDs. However,
studies have shown that the COX-2s have a higher risk of heart attack and
strokes. Vioxx and Bextra were both subsequently...
I was reading through the MyRACentral News Page the other day and an article about Celebrex caught my eye. Celebrex is a non-steroidal anti-inflammatory (NSAID) in the COX-2 inhibitor family. A similar drug, Vioxx, manufactured by rival company Merck, was withdrawn from the market in September 2004 because of increased risk of serious blood clotting, heart attacks and strokes. Three months later the FDA asked Pfizer to voluntarily stop all direct-to-consumer advertising of Celebrex. A few months later, Pfizer also pulled its drug, Bextra, from the market in early 2005, because of a link to a serious skin disorder. Although Pfizer has not advertised, Celebrex has remained on the market because the FDA determined that the benefits of the drug outweigh the significant risks. I haven’t seen the new media or print ads yet, but I think the new spin on the risks that is discussed in the news article is interesting. Apparently, Pfizer begins the...
December 28, 1992, marked a new era for Migraine sufferers with FDA approval of injectable Imitrex (sumatriptan). Imitrex was the first Migraine abortive triptan medication, a class of medications that many Migraineurs would come to call “miracle drugs.” Imitrex tablets were approved by the FDA in 1995. Since then, six more triptans have entered the market – Maxalt , Zomig , Amerge , Axert , Frova , and Relpax . Although triptans are a marked improvement over previous treatment options, many Migraineurs have not been fully satisfied with their results. Some do not achieve full relief from triptans, and the recurrence of Migraines within 24 hours of the first dose has been common. With the patents on sumatriptan nearing their expiration, both generics of the current forms – injections, tablets, and nasal spray – and other medications containing sumatriptan are now in development and testing. The results involving Trexima, one such medication that is a com...
You should know
Answers to your question are meant to provide general health information but should not replace medical advice you receive from a doctor. No answers should be viewed as a diagnosis or recommended treatment for a condition. Content posted by community members does not necessarily reflect the views of Remedy Health Media, which also reserves the right to remove material deemed inappropriate.