On Thursday, April 12 an FDA advisory panel will discuss
whether or not to recommend that the FDA approve Merck & Co’s COX-2
inhibitor, Arcoxia (etoricoxib). The drug is manufactured by Merck, the
same company that made Vioxx, which was pulled from the market in the fall of
2004. Merck applied for approval to sell Arcoxia as a treatment for the
signs and symptoms of osteoarthritis .
Currently, the only COX-2 inhibitor remaining on the market
is Celebrex , made by Pfizer, Inc. These COX-2 inhibitors are all types of
NSAIDs. Over the counter types of NSAIDs include naproxen (sold as Aleve)
and ibuprofen. The difference between the prescription COX-2s and the OTC
NSAIDS (and the big selling point) is that the COX-2s have a lower risk of
bleeding ulcers and other GI complications than other NSAIDs. However,
studies have shown that the COX-2s have a higher risk of heart attack and
strokes. Vioxx and Bextra were both subsequently...
I was reading through the MyRACentral News Page the other day and an article about Celebrex caught my eye. Celebrex is a non-steroidal anti-inflammatory (NSAID) in the COX-2 inhibitor family. A similar drug, Vioxx, manufactured by rival company Merck, was withdrawn from the market in September 2004 because of increased risk of serious blood clotting, heart attacks and strokes. Three months later the FDA asked Pfizer to voluntarily stop all direct-to-consumer advertising of Celebrex. A few months later, Pfizer also pulled its drug, Bextra, from the market in early 2005, because of a link to a serious skin disorder. Although Pfizer has not advertised, Celebrex has remained on the market because the FDA determined that the benefits of the drug outweigh the significant risks. I haven’t seen the new media or print ads yet, but I think the new spin on the risks that is discussed in the news article is interesting. Apparently, Pfizer begins the...
Generic Name: CELECOXIB - ORAL Pronounced: (sell-eh-COX-ib) Celebrex Oral Interactions
Your doctor or pharmacist may already be aware of any
possible drug interactions and may be monitoring you for them. Do not start,
stop, or change the dosage of any medicine before checking with them
This drug should not be used with the following medication
because very serious interactions may occur:
If you are currently using the medication listed above,
tell your doctor or pharmacist before starting celecoxib.
Before using this medication, tell your doctor or
pharmacist of all prescription and nonprescription products you may use,
anti-platelet drugs (e.g., cilostazol,
high blood pressure drugs (including ACE inhibitors such as
captopril, lisinopril and angiotensin II receptor blockers such as losartan,
oral bisphosphonates (e.g., alendronate)
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