On Thursday, April 12 an FDA advisory panel will discuss
whether or not to recommend that the FDA approve Merck & Co’s COX-2
inhibitor, Arcoxia (etoricoxib). The drug is manufactured by Merck, the
same company that made Vioxx, which was pulled from the market in the fall of
2004. Merck applied for approval to sell Arcoxia as a treatment for the
signs and symptoms of osteoarthritis .
Currently, the only COX-2 inhibitor remaining on the market
is Celebrex , made by Pfizer, Inc. These COX-2 inhibitors are all types of
NSAIDs. Over the counter types of NSAIDs include naproxen (sold as Aleve)
and ibuprofen. The difference between the prescription COX-2s and the OTC
NSAIDS (and the big selling point) is that the COX-2s have a lower risk of
bleeding ulcers and other GI complications than other NSAIDs. However,
studies have shown that the COX-2s have a higher risk of heart attack and
strokes. Vioxx and Bextra were both subsequently...
A couple of months back I wrote a post discussing the concerns I and many others have regarding the return of severe gastrointestinal side effects as a result of the increasing use of the so-called traditional anti-inflammatories. This is of course to be expected due to the fears so many patients have now of the sole COX-2 inhibitor remaining on the market in the United States-- Celebrex . Many of my patients are simply refusing to take Celebrex out of fear it "might kill me." The issue of whether the use of COX-2 inhibitors with low-dose aspirin is reasonable for patients at risk of cardiovascular events raised its weary head once more the last few weeks. This time, a provocative article appeared in the December 22, 2007 issue of the British medical journal "The Lancet." The author, a rheumatologist at Stanford University, feels that COX-2 inhibitors are preferable to traditional anti-inflammatories (such as Motrin and Voltaren ) in p...
Generic Name: NAPROXEN SUSTAINED-RELEASE - ORAL Pronounced: (nah-PROX-en) Naproxen sodium Oral Uses
Naproxen is used to relieve pain from various conditions
such as headache, muscle aches, dental pain, menstrual cramps, or arthritis. It
is also used to reduce fever and relieve minor aches and pain due to the common
cold or flu. This medication is known as a nonsteroidal anti-inflammatory drug
(NSAID). It works by blocking your body's production of certain natural
substances that cause inflammation. This effect helps to decrease swelling,
pain, or fever.
If you are treating a chronic condition such as arthritis,
ask your doctor about non-drug treatments and/or using other medications to
treat your pain. See also Warning section.
Do not give this medication to a child younger than 12
years unless directed by a doctor.
How To Use Naproxen sodium Oral
Read all directions on the product package before taking
this medication. If you ...
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