Hello, and welcome to our community. I have been taking Plaquenil for several months now and it has helped me tremendously. It usually doesn't do much of anything until a person has taken it for three months. It has its maximum effect after six months, or so I have been told by my doctors. I felt relief after three months, and then it just got better from there. I am not a doctor or a healthcare professional, but I wouldn't think your flares have anything to do w/the Plaquenil, but you should call your doctor and/or pharmacist and ask this question. They would have the expert knowledge you need. Best Wishes, V
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