If there is one thing I've learned from RA, it's that you need to have a great deal of patience in your life to be able to manage your disease. Everything takes time... time to see doctors, time to get test results, time for insurance to approve meds, time to test out meds to see if they work, rinse and repeat over and over. I know when I was first diagnosed, like you I wanted instant relief and it's really hard still to have to wait day after day, week after week, even month after month for something to make a difference in your pain levels, your ability to do things - particularly when you are trying to live your life, keep your family together, your job going, etc. Unfortunately, that's not the way this disease works.
It took me about 10 months to get fairly stabilized when I was first diagnosed. Humira was my "magic potion" and it kept me going and working for about 4.5 years. Then it started to fail until one day, I was just too sick to move or do much of anything. That was a little over a year ago and I've gone through biologic after biologic trying to find something that will work for me. So far, no success. We're moving to Orencia next since all the TNFs have failed.
I also have an autoimmune liver disease, so I can't take many DMARDS that might increase the effectiveness, so that doesn't weight well in my favor. But with each new medication there is hope on the horizon, you just have to wait it through and give it enough time (usually 2-4 months) to see if its going to work for you. The waiting time is painful, frustrating and depressing but it is part of this disease that plagues us.
I hope you find some relief soon...and as hard as it is to wait for results, be patient with your body and yourself. You will find you're way with this disease. It's a different path for all of us, but you will find yours.
The biologics are all around 67%. There is some research that indicates failing multiple biologics tends to lower your personal chances (but I believe that's just funny statistics).
You might ask about Orencia next, instead, but honestly, it's all about finding the one drug that will work. Personally, I've tried: remicade, enbrel, humira, orencia with no luck. MTX and Arava work like gang busters, but kill my liver...
Both the drugs you've tried are TNF alpha inhibitors. You may just need to try a different class of drugs. There are T cell inhibitors, B cell inhibitors, Interleukin -6 and Interleukin - 1 inhibitors.
Don't be scared to try infusion. It doesn't mean you're more sick - it just means the drug needs to be delivered in a different way. In fact, many infusion drugs eventually develop injection pens for home use.
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