Many people do find that stress exacerbates the symptoms, so it's possible.   I'm a firm convert to Humira - used to be on Enbrel, but it gave me some side effects that meant I couldn't continue. Humira has done wonders for me and my quality of life for five years now, so I hope it'll work as well for you. If you haven't done your first shot yet, be aware that it stings like mad. If you inject it in your belly, pinch the flab (that we all have, so it's okay to say it) hard and hold the pinch while you're injecting. It reduces the sting, although it's quite normal to swear like a sailor anyway.   Some people also find that icing the injection site for several minutes before the shot makes it easier.