I'd noticed that Enbrel stung in a nasty way, too, so it wasn't a shock when the Humira made me say words generally reserved for stubbing toes on the marble table in our living room or getting cut off in heavy traffic.     I wonder if giving it a month to work will be enough?  Dr. L wanted more of a response from Enbrel and says he doesn't hold out a great deal of hope that I'll react better to Humira and really wanted to go with the Actemra.  I'm such a baby about this.  The thought of IV drugs is a big stumbling block for me.  I associate IV medication with being really sick.  I don't want to be that sick!