I was at a RA/OA forum last night and the keynote speaker - one of Canada's leading rheumatologists - talked about how presently, no one really knows why some people respond to one medication/biologic or and some to another. He also mentioned that it's very difficult to predict how a person is going to respond to a medication. Which leads me to believe that your doctor may be pushing Actemra because it worked well for someone else who didn't respond well to Enbrel. Of course, I'm not a doctor, so I could be wrong on that.   Humira usually acts somewhat slower than Enbrel and can take up to three months to really kick in. I changed from Enbrel to Humira and when I made the switch, I had a couple of anxious months. My doctor told me to play with the dosages and how often I took the medication. It turned out that getting my shot every 9-10 days works best for me - the recommended every two weeks is not enough. Some people also find that increasing the recommended dose can be helpful. If the medication doesn't work after about one month, which should be two dosages, talk to your doctor about trying every 10 days or increasing the dose.   I hear you on the IV - I don't want to do that, either, mostly because I don't want to have the kind of life where I have to dedicate a full day to go get an infusion. I don't have time for that and it would make me feel too sick. Still, if there were no options, I'd do it, but I would pout about it. There is at least one other Biologic that is also administered by injection - Simponi is one and it's possible that there's another one, although details fail me. It's Friday afternoon and my brain has left early for the weekend.   Keep me posted, please?