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Hi Mary; I have been taking Plaquenil, Naprosyn, Metho since Oct 2007 and have had no side affects (that I am aware of) My RA has improved greatly since that time.It is much more tolerable and I am definately stronger and more functional. I take my Metho dose on Friday night before bed but I have missed it occasionally and have taken it in the morning and I have never experienced stomach issues. With that said, we all react differently to meds so I think you will just have to test them and find out what suits you best. Best wishes. Jeannette

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