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I agree that everyone's body reacts differently. I take methotrexate, but I do get an upset stomach from it: usually a little nausea the first day and diarrhea for 2-3 days afterwards. But I've tried going without MTX and my RA is too painful to handle without it...so at this point, I'm just trying to cope with the side effects. I take it on weekends so that the worst of the symptoms can be dealt with at home.

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