Thursday, April 14, 2011 Thrive With RA™, Community Member, asks

Q: Anyone Seronegative RA with family history of RA?

How many that are Seronegative RA have a family history of RA?  I am fourth generation RA -- all from the same family line.  I'm curious if others are similar.

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Answers (5)
Lisa Emrich, Health Guide
4/21/11 10:51am

I am seronegative and had two greatgrandmothers who had RA.  A cousin of mine was just dx with RA last year (do not know if she's seroneg or not).  As far as I know, no others in the family have/had RA but there are a lot of other autoimmune diseases on one side of the family.

wonderwoman, Community Member
4/15/11 4:40am

I am third generation ra and sero negative, I don't know whether my mother and grandmother were sero negative or not

andrew, Community Member
4/21/11 1:01pm

I have seronegative RA. No family history of RA but others with autoimmune problems including Hashimoto's (hypothyroidism), psoriasis, and ankylosing spondylitis. My doc tells me that autoimmune tends to run in families.


Thrive With RA™, Community Member
4/21/11 1:12pm

Thank you all for your comments thus far.  It amazes me that despite family history of RA in many cases, there has not been a definitive statement by the medical profession that RA is indeed genetic, only that it "may be" genetic.  I suppose that applies to those that have RA with no family history, but it seems a bit vague for a disease that affects 1.3 M Americans. 

Thrive With RA™, Community Member
4/21/11 1:38pm

I have only seen the American statistic of 1.3 M for those with RA. Anyone have a global statistic?

Brad, Health Guide
4/21/11 10:10pm

I am sero negative RA, both my great grandfathers we think had it as well, they were crippled up pretty bad, but had no real healthcare to speak of. My Rheumy told me his sero neg pts tend to have a more severe case and are harder to control than sero pos. Lucky us!!



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By Thrive With RA™, Community Member— Last Modified: 04/21/11, First Published: 04/14/11