I've had RA since Dec 2007, diagnosed officially in January, 2008. I take methotrexate and Humira every week. They seem to be helping a lot; however, once in a while my wrist will hurt and I'll have to wear a splint for a day - is that a flare or am I just overusing or incorrectly using or placing that particular joint which leads to the pain? I've heard people talk about flare ups, but I don't really understand what it means. Could someone explain what they are and how long they last. Thanks.