Friday, May 08, 2009 Charlotte, Oxford, UK asks

Q: TNF drug or antibiotic causing butterfly rash? Lupus side effect?

A 54 female friend (here in the UK) with longstanding RA, well controlled for past few months with the TNF Adalimumab, recently had a bad chest infection, treated with antibiotics, and then, a week later, developed a butterfly rash and rash on hands and up arms, apparently photosensitve. Her GP changed the antibiotics but was not too concerned as the rash is fading. However I understand this can be a symptom of cutaneous SLE - a rare reaction to TNF that can show some months after treatment begins. She wants to know whether to give herself the next TNF injection now as its a week overdue. She has not been able to speak to her rheuamtologist but the nurse at the clinic seemed to think this could just be an allergic reaction to antibiotics.  Is this possible?  I myself can find no reference to antibiotics causing a classic butterfly rash (with white nose). I am concerned she gets more info asap. The RA helplines are all now closed for the weekend in the UK. Her chest is still not clear. Only other symptom is tiredness.

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Answers (2)
Brad, Health Guide
5/11/09 1:29am

I am no doctor, but from what I have read if the rash is raised it sound more like Lupus to me. You mention Lupus side effect, does she have Lupus as well?

 

Brad

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5/11/09 3:31am

It is possible to get a reaction form antibiotics that will give you a form of lupus called drug induced lupus. Caused by specific medications. Symptoms are similar to those of SLE (arthritis, rash, fever, and chest pain) that typically go away when the drug is stopped. So after you finish all your medications, you should go back to normal. If they presist then you would want to have bloodwork done with an ANA test to see if you test positive, that is for LUPUS. But I have heard of this many times and because you are on medication, after you finish the course it goes away. Good luck!  I copied this right out of my LUPUS Book!!

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By Charlotte, Oxford, UK— Last Modified: 12/27/10, First Published: 05/08/09