Wednesday, July 01, 2009 Brad, Health Guide, asks

Q: Humira question.

Since I had my first injection of Humira, my knees and ankles have hurt so bad it's enough to bring tears to my eyes by the end of the day. I have not seen any difference from the injection, other than increased pain in these joints. Is it possible that it has inflamed them? I take my next injection a week from today, and frankly, I am not looking forward to it at this point. I know it may take time for it to kick in, but I am also hoping this is just wierd timing for my knees and ankles to flare up so badly. They have always hurt, but this is over the top pain. Any ideas?

Brad

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Answers (3)
Lene Andersen, Health Guide
7/ 3/09 12:19pm

Joint pain can be one of the side effects of drugs like the Biologics. I don't as much get joint pain after my shot as muscle pain, which can get pretty intense for couple of days. For me, the benefits outweigh the side effects, though.

 

that said, it could also be a bit of a flare. I've forgotten what medication you were on before - Enbrel? - but you could be experiencing the transition flare that can happen when one medication leaves your body and the other one hasn't built up in your system yet. Humira takes 6-8 weeks to really kick in and I remember being quite desperate, especially in the first month or so. My rheumatologist recommended that I mess with the dosing schedule - to me, every 10 days is the ideal, if I got my shot every two weeks, I would be a very unhappy person. I'd recommend you run this by your rheumatologist to check and to maybe change the dosing schedule a little. You're on prednisone, right? Steroid was a really big help for me in bridging the gap between the two meds and I also found that Humira works best for me with a bit of a booster from steroids.

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Brad, Health Guide
7/ 4/09 12:46am

Thanks Lene,

The knee pain has subsided somewhat, I am on Pred as well. I will ask my RA doc about changing up the schedule. He did say I may have to go to once a week,  hopefully that will help! Thanks for the insights!

 

Brad

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7/ 1/09 7:08pm

Hi Brad...I have experienced this with Humira and methotrexate. My joints feel like someone is ripping them from my body. Not sure if it's because the meds are attacking the problems...but yes I have had that same reaction. I notice it for at least a day or two after the injection. Hope this helps.

                                                                Linda

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7/ 2/09 8:02pm

Brad

I was on Enbrel for 3months and my eyes got blood shot and I had skin problems.  It didn't seem to be working as well as it should so they switched me to Humira.  I've injected twice during the past month.  For a day or two after I inject I get terrible stomach cramps and diarrhea.  Then that seems to go away and I feel great for awhile.  Towards the end of the two week period of time, I get achy, especially in joints I've had problems with and have also noticed my toes burn.  I think all of these drugs have side effects but they supposedly stop the joints from deteriorating by stopping the immune response.  Methotrexate injections worked really well but I like to drink alcohol socially and my hair was falling out so I nixed that drug after 4 months. ( requires blood tests every month too). I guess it's pick your poison and weigh if it's doing more good than harm:)  There are several choices out there but my

Rheum likes Humira the best.

Good luck,

Lisa

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By Brad, Health Guide— Last Modified: 12/26/10, First Published: 07/01/09