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Joint pain can be one of the side effects of drugs like the Biologics. I don't as much get joint pain after my shot as muscle pain, which can get pretty intense for couple of days. For me, the benefits outweigh the side effects, though.   that said, it could also be a bit of a flare. I've forgotten what medication you were on before - Enbrel? - but you could be experiencing the transition flare that can happen when one medication leaves your body and the other one hasn't built up in your system yet. Humira takes 6-8 weeks to really kick in and I remember being quite desperate, especially in the first month or so. My rheumatologist recommended that I mess with the dosing schedule - to me, every 10 days is the ideal, if I got my shot every two weeks, I would be a very unhappy person. I'd recommend you run this by your rheumatologist to check and to maybe change the dosing schedule a little. You're on prednisone, right? Steroid was a really big help for me in bridging the gap between the two meds and I also found that Humira works best for me with a bit of a booster from steroids.