For almost 40 years, it has been suspected that folate plays a role in depression. We have a general sense that low folate can cause depressive symptoms, and that treatment with folate (of low folate patients) can help, but it is still debatable whether or not folate supplementation helps people who are not otherwise deficient.

Folate vs. Deplin (R)

Additionally, it is known that some medications, especially seizure meds such as valproate, carbamazepine and to some degree lamotrigine, reduce...