Vioxx (rofecoxib) Drug Information

The removal of Vioxx (rofecoxib), a COX-2 non-steroidal anti-inflammatory drug (NSAID), from the market was the largest prescription-drug withdrawal in history. Merck, the drug's manufacturer, removed Vioxx from the market after studies showed it caused severe heart and cardiovascular problems, including heart attack and stroke. Learn more about Vioxx, its uses and its side effects and the studies that led to its banishment.

Vioxx Questions and Answers from the FDA

Frequently Asked Questions About Vioxx (rofecoxib)

Image of Vioxx and yellow tablets, arthritis medication

Merck & Co. announced that it would withdraw Vioxx from the worldwide market on Sept. 30, 2004. Find out what went wrong.

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Celebrex: The Last COX-2

Facts About Celebrex
Celebrex is the only COX-2 inhibitor available by prescription. Get the facts on Celebrex, its uses and side effects.

Important Facts About Cox-2 Inhibitors

Why We Miss Cox-2 Inhibitors
Some doctors say that the risk of heart problems is still lower with Celebrex than the risk of gastrointestinal problems with other NSAIDs. So what should you take?
Cox-2 Inhibitors Revisited
After the completion of the PRECISION study in 2011, we should finally have definitive information regarding the safety and efficacy of the traditional NSAIDS vs. Celebrex.