The last time I used illegal drugs (28 years ago) I was hearing vocies and extremely paranoid. I haven't drank in 18 years. Alcohol is a depressant. I drank on top of my meds. I was sick until I stopped drinking. So in my opinion, yes, drugs and liquor make sz worse. I don't have any clinical proof, but I have life proof. I hope you find some clarity into your illness and addictions. Be well.
David