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Hello Corra,   By all means, he should get into treatment and stay into treatment, in this case, it would be what's called MICA: Mental Illness/Chemical Abuse treatment that treats both the drug addiction and the mental illness.   Any kind of drug use, particularly heavy marijuana use and meth use, has the potential to cause schizophrenia.  Fergie, the Grammy-winning singer, claimed in an interview that her meth addiction caused her to have schizophrenia-like symptoms.  At once point, she was afraid to go out of the house.   This is serious business.  There could be relapses along the way, so understand the bridge back to life is sometimes a long one.  Support your friend along the way.  Praise him when he's doing well, and stand by him when he's not doing so well.   As for whether Risperdal and Welbutrin could be used together, that's entirely possible.  Log on to www.drugs.com, where you can type in the names of two drugs to see if they interact with each other in a dangerous way when used in combination.   Hope this helps.   Best wishes, cb