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Tuesday, November 24, 2009
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Trilafon Oral

Drug Interactions


Generic Name: PERPHENAZINE - ORAL
Pronounced: (per-FEN-a-zeen)

Trilafon Oral Interactions

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.

This drug should not be used with the following medication because a very serious interaction may occur:

  • sibutramine


If you are currently using the medication listed above, tell your doctor or pharmacist before starting perphenazine.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of:

  • certain drugs used for Parkinson's (e.g., bromocriptine, levodopa, pergolide)
  • certain anticholinergic medications (e.g., dicyclomine, scopolamine)
  • drugs affecting liver enzymes that remove perphenazine from your body (e.g., amiodarone, duloxetine, fluoxetine, paroxetine, ritonavir)


Also report the use of the following drugs, which might increase your risk of a seizure when combined with perphenazine, such as bupropion, isoniazid (INH), other antipsychotic medications (e.g., haloperidol, quetiapine), lithium, tramadol, tricyclic antidepressants (e.g., amitriptyline), and alcohol, among others. Consult your doctor or pharmacist for details.

Tell your doctor or pharmacist if you also take drugs that cause drowsiness such as: certain antihistamines (e.g., diphenhydramine), anti-seizure drugs (e.g., carbamazepine), medicine for sleep or anxiety (e.g., alprazolam, diazepam, zolpidem), muscle relaxants, narcotic pain relievers (e.g., codeine), psychiatric medicines (e.g., chlorpromazine, risperidone, amitriptyline, trazodone).

Check the labels on all your medicines (e.g., cough-and-cold products) because they may contain ingredients that cause drowsiness. Ask your pharmacist about using those products safely.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

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