Warning Note: A wide range of herbal products -- both oral and topical -- may contribute to dermatological problems. Some Chinese herbal creams have been found to contain corticosteroids; mercury or arsenic contaminants have been found in some Ayurvedic therapies. In addition, several oral herbal remedies used for medical or emotional conditions may produce irritation in reaction to sunlight (photosensitivity). They include, but are not limited to, St. John's Wort, kava, and yohimbe.
Chemopreventive agents
Chemopreventive agents include a wide range of substances used for other diseases that may inhibit the development of melanoma. Agents under investigation and showing promise include statins and fibrates (cholesterol-lowering drugs), retinoids (anti-aging skin drugs), nonsteroidal anti-inflammatory drugs (for arthritis and other pain relief), difluoromethylornithine (DFMO), catechins (phytochemicals found in certain foods), and imiquimod (a treatment for warts).
Exercise
Studies have shown that mice with round-the-clock access to an exercise wheel developed skin cancer more slowly when exposed to UVB. Their tumors were also fewer in number and smaller. Analysis of the data suggested that exercise might trigger the death of the developing cancer cells faster than they can grow. Exercise also made the mice lose weight, and the number of tumors decreased as fat disappeared.
Experimental Agents
Ointments that Prevent Skin Cancers on a Molecular Level. Of interest are studies suggesting the compounds that target genetic mechanisms in the skin may prove to be beneficial ingredients in topical products (e.g., creams, lotions) that prevent skin cancers on a molecular level. They include the cytokine interleukin-12 and an enzyme called T4 endonuclease 5 (T4N5).
Sunscreen GuidelinesWhen choosing a sunscreen, look at the ingredients. Preparations that help block UV radiation are sometimes classified as sunscreens or sunblocks, according to the substances they contain. In general, sunscreens contain organic formulas and sunblocks inorganic formulas. However, the term sunblock is used less and less as sunscreens increasingly contain both kinds of ingredients:
Inexpensive products work as well as expensive ones with the same ingredients. Unfortunately, there are still no standards for sunscreens, and even those claiming UVA protection may offer very little. In one study, the average UVA protection from a wide range of brands was only 23%. In fact, the average protection on brands not making the claim was 37%! Organic formulas and inorganic microfine oxides do not protect against visible light, which is a problem for people who have light-sensitive skin conditions, including actinic prurigo, porphyria, and chronic actinic dermatitis. Inorganic sunscreens that protect against visible light and are still cosmetically acceptable are now available in Europe, but not yet in the US. In July 2006, the FDA approved a new sunscreen for protection against UVB and UVA, with a sun protection factor of 15. Anthelios SX, made by L'Oreal, contains the UVA-blocking ingredient ecamsule, previously unavailable in the U.S. but marketed in Europe and Canada since 1993 as Mexoryl SX. Calculating the SPF The sun protection factor (SPF) on all sunscreen labels is a ratio based on the amount of UVB (not UVA) radiation required to turn sunscreen- or sunblock-treated skin red compared to non-treated skin. For instance, people who sunburn in 5 minutes and who want to stay in the sun for 150 minutes might use an SPF 30. The formula would be: 30 (the SPF number) times 5 (minutes to burn) = 150 minutes in the sun. Protection offered by sunscreens may be classified as follows:
SPF Levels by Age Group Certain groups should have higher or lower SPFs depending on age and other factors:
Timing and Amount of Application Apply sunscreen or sunblock liberally as follows:
Possible Hazards of Sunscreens, Sun Avoidance, or Both When used generously and appropriately, sunscreen products and sun avoidance help reduce the severity of many aging skin disorders, including squamous cell cancers. There are certain concerns, however. Sunscreen Use May Not Protect Against Basal Cell and Melanoma Cancers-and May Even Increase the Risk. Although sunscreens help prevent squamous cell carcinomas and other skin disorders, sunscreens do not appear to provide protection against melanoma and some basal cell cancers. In fact, some studies have reported a higher association with sunscreen use and these skin malignancies, though not all studies report such negative results. The reasons for this possible increased risk are unclear, though some theories include the following:
Sunscreens Use May Increase the Risk for Health Problems Related to Sunlight Deficiencies. There is some major concern that underexposure to sunlight, due to the use of sunscreens or sun-avoidance measures, may produce other health problems, such as the following:
The bottom line is that some sunlight is important and even necessary for a healthful and high-quality life. Some experts recommend that adults may benefit from daily moderate tanning (20 to 30 maximum minutes of exposure during lower-risk hours) over a number of days to slowly build up pigment in the skin. |







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