Mccune-albright Syndrome

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Definition

McCune-Albright syndrome is a genetic disease that affects the bones and color (pigmentation) of the skin.


Alternative Names

Polyostotic fibrous dysplasia


Causes, incidence, and risk factors

McCune-Albright syndrome is caused by mutations in the GNAS1 gene. The abnormal gene is present in a fraction, but not all, of the patient's cells (mosaicism).

This disease is not inherited. It is caused by a new change (mutation) to the DNA that occurs in the womb while the baby is developing. This...

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