Acyclovir (Zovirax), valacyclovir (Valtrex), and famciclovir (Famvir) -- the anti-viral pills used to treat genital herpes -- can also treat the cold sores associated with oral herpes. In addition, acyclovir is available in topical form (see below), as is penciclovir (a related drug).
These ointments or creams help shorten healing time and duration of symptoms. However, none are truly effective in eliminating outbreaks.
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