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what i do is not pick my son up at all when he wakes up (which is every two hours throughout the night) let him kind of fuss while i get the bottle then come back and give him the bottle and he will drink it and go back to sleep. If he needs a change ill change him in his bed and it seems to work so much! so maybe if you pick him up try not picking him up or even saying anything to him til you come back with the bottle. I dont know if this is or there is a PROPER way to do this, but this is what i do and it keeps him from staying awake for long periods in the night..