Friday, June 01, 2012
Wednesday, February 25, 2009 Melissa asks

Q: I am taking trazodone and bupropion. How dangerous can this be?

Trazodone and Bupropion. So far I have not had any severe reactions but recently found out that my potassium levels were found to be really high. I also take Detrol LA for a tilted bladder. I am on a few other medications including Theophylline, Levoxyl, Zetia, and Xanax Prn. I was recently taking Seroquel, but was concerned because I was sleeping too hard and unable to be awakened for the first four hours of sleep. My question is how dangerous these combinations could be over a period of time. I did take Tazodone years ago for approx. 3 years and became immune. Approx. 2 years ago it was tried again but with same results 100 mg did not make me sleep. That was when I was taking Seroquel and weened myself off just in last month due to fear of inability to wake up in case of emergency. I have had three different professionals tell me three different things and I am beginning to have to increase my dosage of Trazodone and worry that maybe I need a different medication for sleep.

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The dosage of each drug should be noted.  For example: I  take 150 mg Bupropion once daily to support a general threshhold of well being which seems to work ok for me.  There is a noticeable difference in my personality if I take less.  But I was having trouble with sleep.  My DR. tried me with Trazodone, 50 mg, taken at night which only slightly improved sleep.  The problem being I woke up feeling drowsy and got worse after I took Bupropion. Mirtazapine is too strong for me and along with the accompanying dreams I concluded it wasn't doing me any good, surrely not enough to help me through a good night's sleep.  Be careful: These drugs are very potent and a combination of any two can give you drastic and unintentional results.  Truthfully, I could not put up with a month's long battle with the side effects of either and decided I'm better off getting a half night's sleep off the drugs than on them.  I remain on Bupropion.

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By Melissa— Last Modified: 03/01/11, First Published: 02/25/09