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Hi Dollface: I am not a physician, but work with many, many chronic pain patients. Most of my patients are on some serious pain meds, including percocet, vicodin and even morphine. Most of them are also on trazodone, or Ambien for sleep. They are often given one or two antidepressants as well. So, the short answer is, yes. You can mix these two according to the large number of my referring physicians. Percocet is a narcotic/analgesic/anti-fever medication and trazodone is a benzodiazepine that is used for its relaxing, tranquilizing and sleep effects. If you are taking them as directed, these medications in combination, when monitored by your prescribing doctor should be ok. But ask your doctor this question. If you trust him, then trust his judgment. If not, find a doctor you do trust.   Best of Luck, Dr. Diana Walcutt   *Dr. Walcutt is a Psychologist. Dr. Walcutt's answers are not intended to diagnose or treat any medical or mental disorder. Any information given in a post about medication is for educational purposes only, and primarily to aid you in having an informed discussion with your own Psychiatrist/Physician.