Provigil

If Provigil gives you an allergic reaction, you'll need to avoid it.

Special warnings about Provigil

If you have high blood pressure, liver or kidney problems, or a history of psychosis or drug abuse, use Provigil with caution. Be sure your doctor knows your medical history before you begin this medication.

Provigil should be avoided by people with certain types of heart disease such as mitral valve prolapse. If you've ever had a heart problem, be sure to check with the doctor before using this drug.

Provigil may cause serious skin reactions, such as Stevens-Johnson syndrome (blisters on the skin, mouth, and eyes) and erythema multiforme (a type of herpes that may cause bumps or blisters).

Provigil may impair your judgment, thinking, or motor skills. You should not drive a car or operate hazardous machinery until you know how this medication affects you.

Oral and implantable contraceptives are less effective while you are taking Provigil. You should use an additional method of contraception while you are taking Provigil and for one month after discontinuing this medication.

Possible food and drug interactions when taking Provigil

The effect of combining Provigil with alcohol has not been studied. It's considered wise to avoid alcohol while taking the drug.

If Provigil is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Provigil with any of the following:

• Antidepressants
• Carbamazepine
• Clomipramine
• Cyclosporine
• Diazepam
• Itraconazole
• Ketoconazole
• MAO inhibitors such as antidepressants
• Methylphenidate
• Oral contraceptives and hormonal implants
• Phenobarbital
• Phenytoin
• Propranolol
• Rifampin
• Theophylline
• Warfarin

Special information if you are pregnant or breastfeeding

The possibility of harmful effects during pregnancy has not been ruled out. If you become pregnant or plan to become pregnant, tell your doctor immediately. Provigil is recommended during pregnancy only if the need for therapy outweighs the potential risk.