Chronic Fatigue Sleepiness Muscle Pain

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Fatigue and Sleepiness in Multiple Sclerosis

Fatigue or tiredness is extremely common in Multiple Sclerosis (MS) and is an important cause of disability. The mechanism for this symptom is incompletely understood. Suffice it to say that the complaint is multifactorial and related to pro-inflammatory chemicals, neuro-hormonal activity and where relevant, muscle weakness.


Many patients with chronic disease have fatigue, particularly those with cancer or immune disorders. However, in MS the fatigue is often disproportionately present, i.e....

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